Demonstration of antibody and cellular immune response to brain extract in West and Lennox-Gastaut syndromes.
نویسندگان
چکیده
We investigated humoral and cellular immune response to brain tissues in 15 patients with West syndrome, in 9 patients with Lennox-Gastaut syndrome and in 20 healthy children. High levels of a precipitating antibody to a saline extract of brain tissue were detected in all patients; leucocyte migration inhibition test with the same antigen was found to be positive in most of them. The role of this autoimmune response in the pathogenesis of West and Lennox-Gastaut syndromes remains to the elucidated.
منابع مشابه
Immunological disturbance in West and Lennox-Gastaut syndromes.
Cell-mediated and humoral immunity were investigated in 18 patients with West syndrome, 12 with Lennox-Gastaut syndrome and 19 healthy controls. The study included determination of T and B peripheral blood lymphocytes, serum levels of IgG, IgA and IgM, skin sensibilization with DNCB, intracutaneous PHA, leucocyte migration inhibition test and lymphocyte blastic transformation in the presence of...
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ورودعنوان ژورنال:
- Arquivos de neuro-psiquiatria
دوره 42 2 شماره
صفحات -
تاریخ انتشار 1984